Subsystem: Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway

This subsystem's description is:

Lacto-N-biose I could be a candidate for the bifidus factor, which is responsible for increasing the bifidobacteria population.Intestinal colonization by bifidobacteria is important for human health, especially in pediatrics, because colonization seems to prevent infection by some pathogenic bacteria that cause diarrhea or other illnesses.

For more information, please check out the description and the additional notes tabs, below

Literature ReferencesPurification, crystallization and preliminary X-ray analysis of the galacto-N-biose-/lacto-N-biose I-binding protein (GL-BP) of the ABC transporter from Bifidobacterium longum JCM1217. Wada J Acta crystallographica. Section F, Structural biology and crystallization communications 2007 Sep 117768345
Identification of N-acetylhexosamine 1-kinase in the complete lacto-N-biose I/galacto-N-biose metabolic pathway in Bifidobacterium longum. Nishimoto M Applied and environmental microbiology 2007 Oct17720833
Novel putative galactose operon involving lacto-N-biose phosphorylase in Bifidobacterium longum. Kitaoka M Applied and environmental microbiology 2005 Jun15933016
DiagramFunctional RolesSubsystem SpreadsheetDescriptionAdditional Notes 

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Group Alias
Abbrev.Functional RoleReactionsScenario ReactionsGOLiterature
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Taxonomy Pattern 
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active
LnpALnpBLnpCLnpDABCsbABCp1ABCp2
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Lacto-N-biose I could be a candidate for the bifidus factor, which is responsible for increasing the bifidobacteria population.Intestinal colonization by bifidobacteria is important for human health, especially in pediatrics, because colonization seems to prevent infection by some pathogenic bacteria that cause diarrhea or other illnesses.
The gene cluster of B. longum NCC2705 consists of the open reading frames BL1638 to BL1644. The BL1638 to BL1640 genes were annotated to encode component proteins of an ATP-binding-cassette-type sugar transporter.

========REFERENCES:=============

1. Nishimoto M, Kitaoka M. Identification of N-acetylhexosamine 1-kinase in the complete lacto-N-biose I/galacto-N-biose metabolic pathway in Bifidobacterium longum. Appl Environ Microbiol. 2007 Oct;73(20):6444-9. PMID: 17720833.

2. Wada J, Suzuki R, Fushinobu S, Kitaoka M, Wakagi T, Shoun H, Ashida H, Kumagai H, Katayama T, Yamamoto K. Purification, crystallization and preliminary X-ray analysis of the galacto-N-biose-/lacto-N-biose I-binding protein (GL-BP) of the ABC transporter from Bifidobacterium longum JCM1217. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Sep 1;63(Pt 9):751-3. PMID: 17768345

3. Kitaoka M, Tian J, Nishimoto M. Novel putative galactose operon involving lacto-N-biose phosphorylase in Bifidobacterium longum.
Appl Environ Microbiol. 2005 Jun;71(6):3158-62. PMID: 15933016