Subsystem: Alanine biosynthesis
This subsystem's description is:
At least three pathways (alanine biosynthesis I, alanine biosynthesis II, and alanine biosynthesis III) contribute to the synthesis of alanine.
Taxonomic distribution for the three pathways are as follows:
alanine biosynthesis I: archaea, eubacteria, and eukaryotes
alanine biosynthesis II: archaea and eukaryotes
alanine biosynthesis III: archaea, eubacteria, and eukaryotes.
=============Variant codes:==============
A - main eubacterial pathway with the key enzyme AtvA ( Valine--pyruvate aminotransferase) – “Alanine biosynthesis I pathway”;
A.120 - Alanine biosynthesis I pathway + alanine biosyntheis III pathway ( cysteine desulfurase) = IlvE + AvtA + IscS
A.123 - Alanine biosynthesis I pathway + alanine biosyntheis III pathway ( cysteine desulfurase) + alanine racemase = IlvE + AvtA + IscS + *AlaR;
A.1234 – All above + AlaB (glutamate-pyruvate aminotransferase pathway (eukaryotic);
B - Alanine biosyntheis III pathway, mediated by cysteine desulfurase (archaea, eubacteria, and eukaryotes) = IscS;
C - Alanine biosyntheis III pathway( cysteine desulfurase) and alanine racemase;
IscS + *AlaR, with IlvE or without
D - Alanine biosynthesis II - glutamate-pyruvate aminotransferase pathway (eukaryotic) = AlaB;
E – just alanine racemase present
For more information, please check out the description and the additional notes tabs, below
| Literature References | Cloning and characterization of the Escherichia coli K-12 alanine-valine transaminase (avtA) gene. Wang MD Journal of bacteriology 1987 Sep | 3040683 | Bacterial cysteine desulfurases: their function and mechanisms. Mihara H Applied microbiology and biotechnology 2002 Oct | 12382038 | Functional analysis of all aminotransferase proteins inferred from the genome sequence of Corynebacterium glutamicum. Marienhagen J Journal of bacteriology 2005 Nov | 16267288 |
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| Diagram | Functional Roles | Subsystem Spreadsheet | Description | Additional Notes | Scenarios | |||||||||
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