Subsystem: Alanine biosynthesis

This subsystem's description is:

At least three pathways (alanine biosynthesis I, alanine biosynthesis II, and alanine biosynthesis III) contribute to the synthesis of alanine.
Taxonomic distribution for the three pathways are as follows:
alanine biosynthesis I: archaea, eubacteria, and eukaryotes
alanine biosynthesis II: archaea and eukaryotes
alanine biosynthesis III: archaea, eubacteria, and eukaryotes.

=============Variant codes:==============

A - main eubacterial pathway with the key enzyme AtvA ( Valine--pyruvate aminotransferase) – “Alanine biosynthesis I pathway”;

A.120 - Alanine biosynthesis I pathway + alanine biosyntheis III pathway ( cysteine desulfurase) = IlvE + AvtA + IscS

A.123 - Alanine biosynthesis I pathway + alanine biosyntheis III pathway ( cysteine desulfurase) + alanine racemase = IlvE + AvtA + IscS + *AlaR;

A.1234 – All above + AlaB (glutamate-pyruvate aminotransferase pathway (eukaryotic);

B - Alanine biosyntheis III pathway, mediated by cysteine desulfurase (archaea, eubacteria, and eukaryotes) = IscS;

C - Alanine biosyntheis III pathway( cysteine desulfurase) and alanine racemase;
IscS + *AlaR, with IlvE or without

D - Alanine biosynthesis II - glutamate-pyruvate aminotransferase pathway (eukaryotic) = AlaB;
E – just alanine racemase present

For more information, please check out the description and the additional notes tabs, below

Literature ReferencesCloning and characterization of the Escherichia coli K-12 alanine-valine transaminase (avtA) gene. Wang MD Journal of bacteriology 1987 Sep3040683
Bacterial cysteine desulfurases: their function and mechanisms. Mihara H Applied microbiology and biotechnology 2002 Oct12382038
Functional analysis of all aminotransferase proteins inferred from the genome sequence of Corynebacterium glutamicum. Marienhagen J Journal of bacteriology 2005 Nov16267288
DiagramFunctional RolesSubsystem SpreadsheetDescriptionAdditional NotesScenarios 

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Group Alias
Abbrev.Functional RoleReactionsScenario ReactionsGOLiterature

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