Annotation Overview for fig|93061.3.peg.945 in Staphylococcus aureus subsp. aureus NCTC 8325:
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase (EC 2.2.1.9)

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current assignment	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase (EC 2.2.1.9)	EC Number	2.2.1.9
taxonomy id	93061	contig	NC_007795 (2,821,361bp)
internal links	genome browser | feature evidence | sequence	ACH Annotation Clearinghouse (ACH) The Annotation Clearinghouse offers a mapping of genes which are identical in sequence except for the start region (due to differences in start calling). [?]	show essentially identical genes
annotation history		run tool	Psi-BlastTMpredTMHMMGram negative PSORTGram negative SignalPGram positive PSORTGram positive SignalPLipoPRadarPPSearchGram negative CELLOGram positive CELLOProDomPDBRNAFold
FigFam	FIG00000866	CDD link	show cdd
PATtyfam	PGF_00414366: 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase (EC 2.2.1.9) PLF_1279_00000135: 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase (EC 2.2.1.9)
alignments and trees	2 alignments and trees
edit functional role	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase (EC 2.2.1.9)
aliases	GO:0000287 GO:0008683 GO:0009234 GO:0030145 GO:0030976 GO:0070204 GeneID:3920128 LocusTag:SAOUHSC_00983 YP_499536.1 cds.945 cmr|NT05SA0891 cmr|SACOL1052 cmr|SAUSA300_0946 dbj|BAF67185.1 gb|AAW36517.1 gb|ABD22875.1 gb|ABD30108.1 gb|ABX29011.1 gb|EES98103.1 gb|EEV83054.1 gb|EEW44326.1 gb|EEW47064.1 gi|122539837 gi|123486474 gi|150373925 gi|151221125 gi|160368040 gi|161509231 gi|193806123 gi|193806124 gi|221138021 gi|221141827 gi|253729374 gi|253732596 gi|257860222 gi|258452007 gi|259159268 gi|259162495 gi|57284423 gi|57650237 gi|81694793 gi|87128361 gi|87162387 gi|87202298 gi|88194740 gnl|md5|c8de85fdad88a29b983407f4 img|637151816 img|637887598 img|637893629 img|640795293 img|641308961 kegg|saa:SAUSA300_0946 kegg|sac:SACOL1052 kegg|sae:NWMN_0913 kegg|sao:SAOUHSC_00983 kegg|sax:USA300HOU_0991 ref|YP_001331947.1 ref|YP_001574890.1 ref|YP_185917.1 ref|YP_493644.1 ref|YP_499536.1 ref|ZP_03562823.1 ref|ZP_03566320.1 ref|ZP_04866761.1 ref|ZP_05700023.1 sp|A6QFQ3 sp|A8Z0D7 sp|MEND_STAA3 sp|MEND_STAA8 sp|MEND_STAAC sp|MEND_STAAE sp|MEND_STAAT sp|Q2FI34 sp|Q2FZL7 sp|Q5HH40 tr|C5PY01	propagation lock	Unlocked Toggle lock

Annotation History (history of similar genes)

Date	Annotator	Annotation
9/28/2004	MattC	Set master function to menaquinone biosynthesis / 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase / 2-oxoglutarate decarboxylase (EC 4.1.1.71)
1/11/2005	OlgaZ	Set master function to 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase / 2-oxoglutarate decarboxylase (EC 4.1.1.71)
1/11/2005	OlgaZ	Set master function to 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase (EC 4.1.3.-) / 2-oxoglutarate decarboxylase (EC 4.1.1.71)
7/27/2005	OlgaZ	Set master function to 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase (EC 2.5.1.64) / 2-oxoglutarate decarboxylase (EC 4.1.1.71)
5/4/2006	ncbi	Set master function to 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylic acid synthase/2-oxoglutarate decarboxylase
9/9/2008	OlgaZ	Set master function to 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase (EC 2.2.1.9) / 2-oxoglutarate decarboxylase (EC 4.1.1.71)
9/9/2008	OlgaZ	Master function set by OlgaZ at 1221020344 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase (EC 2.2.1.9) / 2-oxoglutarate decarboxylase (EC 4.1.1.71)
10/30/2008	OlgaZ	Set master function to 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase (EC 2.2.1.9)

We have assigned the function "2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase (EC 2.2.1.9)" to the encoded protein. The protein occurs in 2 subsystems: "Menaquinone and Phylloquinone Biosynthesis", and "Menaquinone biosynthesis from chorismate via 1,4-dihydroxy-2-naphthoate". In "Menaquinone and Phylloquinone Biosynthesis", it appears to play a functional role that we have not associated with any other gene. The function of genes having the same functional roles have been described in Bacillus subtilis (8566759). This is a homologous protein which implements the same function.

The chromosomal region of the focus gene (top) is compared with four similar organisms. The graphic is centered on the focus gene, which is red and numbered 1. Sets of genes with similar sequence are grouped with the same number and color. Genes whose relative position is conserved in at least four other species are functionally coupled and share gray background boxes. The size of the region and the number of genomes may be reset. Click on any arrow in the display to refocus the comparison on that gene. The focus gene always points to the right, even if it is located on the minus strand.