Annotation Overview for fig|282459.1.peg.2224 in Staphylococcus aureus subsp. aureus MSSA476:
TetR family regulatory protein of MDR cluster

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current assignment	TetR family regulatory protein of MDR cluster
taxonomy id	282459	contig	NC_002953 (2,799,802bp)NC_005951 (20,652bp)
internal links	genome browser | feature evidence | sequence	ACH Annotation Clearinghouse (ACH) The Annotation Clearinghouse offers a mapping of genes which are identical in sequence except for the start region (due to differences in start calling). [?]	show essentially identical genes
annotation history		run tool	Psi-BlastTMpredTMHMMGram negative PSORTGram negative SignalPGram positive PSORTGram positive SignalPLipoPRadarPPSearchGram negative CELLOGram positive CELLOProDomPDBRNAFold
CDD link	show cdd
PATtyfam	PGF_00056263: TetR family regulatory protein of MDR cluster PLF_1279_00002099: TetR family regulatory protein of MDR cluster
alignments and trees	13 alignments and trees
edit functional role	TetR family regulatory protein of MDR cluster
aliases	GeneID:2863991 SAS2245 YP_044358.1 gi|49487137	propagation lock	Unlocked Toggle lock

Annotation History (history of similar genes)

Date	Annotator	Annotation
9/2/2005	annotation_repair	Annotation for existing assignment TetR family regulatory protein
9/2/2005	annotation_repair	Set master function to TetR family regulatory protein
11/2/2006	RossO	Set function to TetR family regulatory protein of MDR A/B cluster
11/2/2006	RossO	These should be assigned only when they occur divergently from the protein A/protein B cluster.
11/2/2006	RossO	Set master function to TetR family regulatory protein of MDR cluster

We have assigned the function "TetR family regulatory protein of MDR cluster" to the encoded protein. The protein occurs in 1 subsystem: "Multidrug Resistance, 2-protein version Found in Gram-positive bacteria". In "Multidrug Resistance, 2-protein version Found in Gram-positive bacteria", it appears to play a functional role that we have not associated with any other gene, and it occurs in close proximity on the chromosome with another gene from the same subsystem.

The chromosomal region of the focus gene (top) is compared with four similar organisms. The graphic is centered on the focus gene, which is red and numbered 1. Sets of genes with similar sequence are grouped with the same number and color. Genes whose relative position is conserved in at least four other species are functionally coupled and share gray background boxes. The size of the region and the number of genomes may be reset. Click on any arrow in the display to refocus the comparison on that gene. The focus gene always points to the right, even if it is located on the minus strand.