Subsystem: Urease subunits
This subsystem's description is:
Urease is a nickel metallo enzyme that catalyzes the degredation of urea to ammonia and carbamine acid. The latter compound decomposes spontaneously to form a second molecule of ammonia and carbon dioxide.
The enzyme consists of three subunits, alpha, beta and gamma. This heterotrimer forms multimers, mainly trimers.
UreA and UreB = needed for the association of the urease heterotrimer UreABC
UreC = catalytic domain containing an active site with a Ni2+ center complexed by a carbamylated lysine
UreE = metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease
UreF = modulates activation of urease by eliminating Ni2+ irons from the non-carbamylated protein
UreG = GTP hydrolase needed for the assembly of the Ni2+ metallocenter of urease
UreD = needed for the assembly of the Ni2+ metallocenter
Nomenclature for urease subunits in Helicobacter might differ from this SS
For more information, please check out the description and the additional notes tabs, below
|Literature References||Proteus mirabilis urease: nucleotide sequence determination and comparison with jack bean urease. Jones BD Journal of bacteriology 1989 Dec||2687233||Characterization of the urease operon of Brucella abortus and assessment of its role in virulence of the bacterium. Sangari FJ Infection and immunity 2007 Feb||17101645||Organization of Ureaplasma urealyticum urease gene cluster and expression in a suppressor strain of Escherichia coli. Neyrolles O Journal of bacteriology 1996 Feb||8550495||Urease of Corynebacterium glutamicum: organization of corresponding genes and investigation of activity. Nolden L FEMS microbiology letters 2000 Aug 15||10930756||Shuttle cloning and nucleotide sequences of Helicobacter pylori genes responsible for urease activity. Labigne A Journal of bacteriology 1991 Mar||2001995||UreG, a chaperone in the urease assembly process, is an intrinsically unstructured GTPase that specifically binds Zn2+. Zambelli B The Journal of biological chemistry 2005 Feb 11||15542602|
|Web links||Model of K. aerogenes urease activation|
|Diagram||Functional Roles||Subsystem Spreadsheet||Description||Additional Notes|
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