Subsystem: Tricarboxylate transport system

This subsystem's description is:

Tricarboxylates are transported into Salmonella typhimurium by a binding protein-dependent transport system known as TctI. Genetically, it comprises three structural genes, tctCBA (where TctC is a periplasmic tricarboxylate-binding protein, TctA and TctB are inner membrane protein components), as well as a transcriptional regulator TctD and a sensor protein TctE. The transport system tctCBA is present in many other organisms. In some of them additional genes (i.g. in Pseudomonads coding for porins) have become parts of the operon and suggest a specialization for some particular substartes that have yet to be determined.

For more information, please check out the description and the additional notes tabs, below

Literature ReferencesGenetic regulation of the tricarboxylate transport operon (tctI) of Salmonella typhimurium. Widenhorn KA Journal of bacteriology 1989 Aug2666399
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TctATctBTctCTctDTctEAMOOpdH
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Tricarboxylates are transported into Salmonella typhimurium by a binding protein-dependent transport system known as TctI. Genetically, it comprises three structural genes, tctCBA (where TctC is a periplasmic tricarboxylate-binding protein, TctA and TctB are inner membrane protein components), as well as a transcriptional regulator TctD and a sensor protein TctE. The transport system tctCBA is present in many other organisms. In some of them additional genes (i.g. in Pseudomonads coding for porins) have become parts of the operon and suggest a specialization for some particular substartes that have yet to be determined.
This SS is derived from CBSS-49338.1.peg.459 (by OlgaV) and will probably replace it.

Fractionation studies have demonstrated that the TctC periplasmic binding protein of Salmonella serovar Typhimurium interacts with both the outer and inner membranes and may funnel substrates from one membrane to the other. In Pseudomonas aerogenosa it was shown that the porin OpdH is tricarboxylate specific (cis-aconitate, isocitrate, citrate), even though no specific binding site were found within the channel.