Subsystem: Tn552

This subsystem's description is:

Transposon Tn552 contains three genes involved in -lactamase production, the blaZ -lactamase gene and two linked genes controlling its expression, blaI and blaR. They constitute the right half of the transposon (the Tn552 bla gene module). The left half of Tn552 (the mobility module) comprises the genes tnpA (p480), which encodes a transposase; tnpB (p271), which encodes an ATP-binding protein; binL, which encodes a resolvase/integrase (recombinase); and a resolution site, resL. Tn552 is flanked by inverted terminal repeats of 116 bp (TIRL and TIRR). Tn552 generates 6 bp (rather than 5 bp) flanking direct repeats of target DNA. The presence of intact transposons and insertion sequence (IS) elements may lead to a variety of genetic rearrangements including deletions, inversions, and translocations. The naturally occurring staphylococcal plasmid, pI9789, contains a Tn552-derived resolution system ('resR-binR') that acts as a 'hotspot' for Tn552 transposition; insertion creates a segment of DNA flanked by inversely repeated resolution sites, one (resR) on pI9789 and the other (resL) on Tn552. Production of -lactamase is one of the mechanisms by which staphylococci become resistant to -lactam antibiotics.

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Literature ReferencesCharacterization of the staphylococcal beta-lactamase transposon Tn552. Rowland SJ The EMBO journal 1989 Sep2555186
DiagramFunctional RolesSubsystem SpreadsheetDescriptionAdditional Notes 

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Group Alias
Abbrev.Functional RoleReactionsScenario ReactionsGOLiterature
SubsetsColoring
collapsed
expanded


  
Taxonomy Pattern 
Organism 
Domain
Variant [?] 
active
tnpBtnpAbinblaIblaR1blaZ
Transposon Tn552 contains three genes involved in -lactamase production, the blaZ -lactamase gene and two linked genes controlling its expression, blaI and blaR. They constitute the right half of the transposon (the Tn552 bla gene module). The left half of Tn552 (the mobility module) comprises the genes tnpA (p480), which encodes a transposase; tnpB (p271), which encodes an ATP-binding protein; binL, which encodes a resolvase/integrase (recombinase); and a resolution site, resL. Tn552 is flanked by inverted terminal repeats of 116 bp (TIRL and TIRR). Tn552 generates 6 bp (rather than 5 bp) flanking direct repeats of target DNA. The presence of intact transposons and insertion sequence (IS) elements may lead to a variety of genetic rearrangements including deletions, inversions, and translocations. The naturally occurring staphylococcal plasmid, pI9789, contains a Tn552-derived resolution system ('resR-binR') that acts as a 'hotspot' for Tn552 transposition; insertion creates a segment of DNA flanked by inversely repeated resolution sites, one (resR) on pI9789 and the other (resL) on Tn552. Production of -lactamase is one of the mechanisms by which staphylococci become resistant to -lactam antibiotics.
variant code 1 = 1 or more complete Tn552 present
variant code -1 = no Tn552 pieces found
variant code 0 = work in progress

282459.1 Staphylococcus aureus subsp. aureus MSSA476 tnpA peg called short
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Rowland SJ, Dyke KG
Characterization of the staphylococcal beta-lactamase transposon Tn552.
EMBO J. 1989 Sep;8(9):2761-73
http://www.pubmedcentral.gov/pagerender.fcgi?artid=401285&pageindex=8