Subsystem: SigmaB stress responce regulation
This subsystem's description is:
The general stress regulons in different bacteria are controlled by the activity state of sigmaB, a transcription factor that is switched on following exposure to either physical or nutritional stress.Physical interactions between RsbU-RsbV, RsbV-RsbW, and RsbW-sigma(B) were inferred from a yeast (Saccharomyces cerevisiae) two-hybrid approach, indicating the presence of a partner-switching mechanism in the sigma(B) activation cascade. Operon comprised by sa2059-sa2058-rsbU-rsbV-rsbW-sigB genes in Staphylococcus which contains all the regulatory pathway genes and an anlogous operon in Bacilli were basic for this SS.
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