Subsystem: SecY2-SecA2 Specialized Transport System

This subsystem's description is:

The SecY2-SecA2 locus seems to implement a specialized transport system. In

An accessory sec locus of Streptococcus gordonii is required for export of the surface protein GspB and for normal levels of binding to human platelets

Bensing and Sullam say that it "may constitute a specialized system for the transport of a very large serine-rich repeat protein".

I have tried to map the cluster accurately to the Staph, Lactobacilii, and Pediococcus genomes we currently have.

For more information, please check out the description and the additional notes tabs, below

DiagramFunctional RolesSubsystem SpreadsheetDescriptionAdditional Notes 

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Taxonomy Pattern 
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SecY2GftAAsp2_3SecA2GftBAsp1Asp2_7
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The SecY2-SecA2 locus seems to implement a specialized transport system. In

An accessory sec locus of Streptococcus gordonii is required for export of the surface protein GspB and for normal levels of binding to human platelets

Bensing and Sullam say that it "may constitute a specialized system for the transport of a very large serine-rich repeat protein".

I have tried to map the cluster accurately to the Staph, Lactobacilii, and Pediococcus genomes we currently have.
Identification of a Candidate Streptococcus pneumoniae Core Genome and Regions of Diversity Correlated with Invasive Pneumococcal Disease

Caroline Obert, Jack Sublett, Deepak Kaushal, Ernesto Hinojosa, Theresa Barton, Elaine I. Tuomanen, and Carlos J. Orihuela1

for a description of the locus (see Table 2). Note that the two very small genes Asp4 and Asp5 may exist, but not called, in a number of our genomes. I will try to fill them in and then extend the set of roles.
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Mol Microbiol. 2002 May;44(4):1081-94

An accessory sec locus of Streptococcus gordonii is required for export of the surface protein GspB and for normal levels of binding to human platelets.
Bensing BA, Sullam PM.


The translocation of proteins across the bacterial cell membrane is carried out by highly conserved components of the Sec system. Most bacterial species have a single copy of the genes encoding SecA and SecY, which are essential for viability. However, Streptococcus gordonii strain M99 encodes SecA and SecY homologues that are not required for viability or for the translocation of most exported proteins. The genes (secA2 and secY2) reside in a region of the chromosome required for the export of GspB, a 286 kDa cell wall-anchored protein. Loss of GspB surface expression is associated with a significant reduction in the binding of M99 to human platelets, suggesting that it may be an adhesin. Genetic analyses indicate that M99 has a second, canonical SecA homologue that is essential for viability. At least two other Gram-positive species, Streptococcus pneumoniae and Staphylococcus aureus, encode two sets of SecA and SecY homologues. One set is more similar to SecA and SecY of Escherichia coli, whereas the other set is more similar to SecA2 and SecY2 of strain M99. The conserved organization of genes in the secY2-secA2 loci suggests that, in each of these Gram-positive species, SecA2 and SecY2 may constitute a specialized system for the transport of a very large serine-rich repeat protein.

PMID: 12010500