Subsystem: Purine conversions
This subsystem's description is:
Purine compound conversions play an important role in cell's nucleotide balance redirecting sourses of energy and bases between different biosynthetic pathways. It is also forms one of the central networks in cell signaling.
On absence of purine biosynthesis parasitic microorganims depend on purine salvage pathways by reusing compounds which they can transport from their host cells. A. pernix does not encode enzymes of the de novo purine biosynthesis pathway (unlike the euryarchaea with completely sequenced genomes). The enzymes for interconversion of IMP, GMP and AMP are present, and it appears likely that A. pernix partly relies on salvage pathways for the formation of purine nucleotides, but also probably imports nucleosides and/or bases into the cell. In this respect, A. pernix is similar to such parasitic bacteria as H. pylori, Borrelia burgdorferi, and Chlamydia that do not possess purine biosynthesis capabilities either and import nucleosides or bases from the surrounding medium. (For more details see:(Natale DA, Shankavaram UT, Galperin MY, Wolf YI, Aravind L, Koonin EV. Towards understanding the first genome sequence of a crenarchaeon by genome annotation using clusters of orthologous groups of proteins (COGs).
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