Subsystem: Proline Synthesis
This subsystem's description is:
This universal pathway is found in organisms ranging from bacteria to H. sapiens.
However, the first reaction (conversion of 2-oxoglutarate to glutamate) is catalyzed by different enzymes in different organisms.
In mammals, this reaction occurs in the mitochondrial matrix by an NAD(P)+-dependent glutamate dehydrogenase (EC 220.127.116.11). Glutamate is then transported to the cytoplasm, where the rest of the reactions occur.
In bacteria, the first step is catalyzed by a NADP+-dependent enzyme (EC 18.104.22.168).
Net Reaction Equation: glutamate + ATP + 2 NADPH = L-proline + 2 NADP+ + Pi
gdhA and proB enzymes form a complex necessary for the activity of the first enzyme -glutamate dehydrogenase
For more information, please check out the description and the additional notes tabs, below
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