Subsystem: Polyadenylation bacterial
This subsystem's description is:
For more information, please check out the description and the additional notes tabs, below
|Diagram||Functional Roles||Subsystem Spreadsheet||Additional Notes|
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Bacterial RNA polyadenylation apears to be a signal for RNA degradation.
1 = poly(A) polymerase without Hfq
2 = poly(A) polymerase and Hfq
Hfq is included because of evidence for a functional association with poly(A) polymerase:
Mohanty, B. K., Maples, V. F., and Kushner, S. R. 2004. The Sm-like protein Hfq regulates polyadenylation dependent mRNA decay in Escherichia coli. Mol. Microbiol. 54: 905-920.
Hfq protein has limited phylogenetic distribution. PSI-BLAST very impressively finds a set of proteins, and nothing else close.
Present in Aquifex
Present in Thermotoga
Present in many, but not all Proteobacteria (no epsilons, not rickettsia group)
Present Leptospira, but not Treponema
Present in Bacillus and relatives, but not in most low G+C gram positives
not in high G+C gram positives
not in cyanobacteria
not in Chloroflexus
not in Deinococcus and Thermus
not in Chlamydia group
Polyribonucleotide nucleotidyltransferase is included because of evidence for functional association.
tRNA nucleotidyltransferase (EC 18.104.22.168) is included because it is a difficult-to-separate paralogue of Poly(A) polymerase (EC 22.214.171.124).