Subsystem: N-heterocyclic aromatic compound degradation

This subsystem's description is:

The azaarenes (nitrogen-containing heterocyclic aromatic hydrocarbons) are products of incomplete combustion processes and thus are widely distributed with tar and oil products in the environment.The aerobic bacterial degradation of these growth substrates frequently involves several hydroxylation steps and subsequent dioxygenolytic cleavage of (di)hydroxy-substituted heteroaromatic intermediates to aliphatic metabolites which finally are channeled into central metabolic pathways. As a rule, the initial bacterial hydroxylation of a N-heteroaromatic compound is catalyzed by a molybdenum hydroxylase, which uses a water molecule as source of the incorporated oxygen.
Quinoline, a N-heterocyclic aromatic compound, can be degraded by microbes along different pathways.
Here we show the most genearl functions involvd in quinoline degradation.

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DiagramFunctional RolesSubsystem SpreadsheetDescriptionAdditional Notes 

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The azaarenes (nitrogen-containing heterocyclic aromatic hydrocarbons) are products of incomplete combustion processes and thus are widely distributed with tar and oil products in the environment.The aerobic bacterial degradation of these growth substrates frequently involves several hydroxylation steps and subsequent dioxygenolytic cleavage of (di)hydroxy-substituted heteroaromatic intermediates to aliphatic metabolites which finally are channeled into central metabolic pathways. As a rule, the initial bacterial hydroxylation of a N-heteroaromatic compound is catalyzed by a molybdenum hydroxylase, which uses a water molecule as source of the incorporated oxygen.
Quinoline, a N-heterocyclic aromatic compound, can be degraded by microbes along different pathways.
Here we show the most genearl functions involvd in quinoline degradation.
Fetzner S.
Abstract Enzymes involved in the aerobic bacterial degradation of N-heteroaromatic compounds: molybdenum hydroxylases and ring-opening 2,4-dioxygenases.
Naturwissenschaften. 2000 Feb;87(2):59-69. Review.
Entries 3,4 are general: no candidates yet.
1H-3-hydroxy-4-oxoquinoline 2,4-dioxygenase-no sequence?-I can find nothing related.


Willumsen PA, Johansen JE, Karlson U, Hansen BM., Isolation and taxonomic affiliation of N-heterocyclic aromatic hydrocarbon-transforming bacteria. Appl Microbiol Biotechnol. 2005 May;67(3):420-8. Epub 2005 Jan 14.