Subsystem: Murein hydrolase regulation and cell death

This subsystem's description is:

The cidABC and lrgAB operons regulate programmed cell lysis shown originally in Staphylococcus aureus. CidA is a pro-lytic protein that increases murein hydrolysis, whereas LrgA and/or LrgB is anti-lytic by the way of decreasing murein hydrolase activity. CidA and LrgA are proposed to be analogous to the holin/antiholins of bacteriophages and the Bax/Blc apoptotic system in eukaryota.

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Literature ReferencesThe LysR-type transcriptional regulator, CidR, regulates stationary phase cell death in Staphylococcus aureus. Chaudhari SS Molecular microbiology 2016 Sep27253847
Transcription of the Staphylococcus aureus cid and lrg murein hydrolase regulators is affected by sigma factor B. Rice KC Journal of bacteriology 2004 May15126464
The Staphylococcus aureus cidAB operon: evaluation of its role in regulation of murein hydrolase activity and penicillin tolerance. Rice KC Journal of bacteriology 2003 Apr12670989
The biological role of death and lysis in biofilm development. Bayles KW Nature reviews. Microbiology 2007 Sep17694072
DiagramFunctional RolesSubsystem SpreadsheetDescriptionAdditional Notes 

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