Subsystem: Multidrug Resistance, 2-protein version Found in Gram-positive bacteria
This subsystem's description is:
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3-protein systems exist in gram negative bacteria. They are composed of an inner membrance component (IM), an outer membrane component (OM) and a periplasmic accessory protein (often called a membrane fusion protein). ---- See "Multidrug Resistance Mechanisms: Drug Efflux Across Two Membranes" by Zgurskaya and Nikaido, Molecular Microbiology (2000) 37(2), 219-225 ---- "Structure and Function of Efflux Pumps that Confer Resistancde to Drugs" by Borges-Walmsley, McKeegan, Walmsley Biochem J. (2003) 376, 313-338 ---- Multidrug efflux systems in Gram-negative bacteria" by Moreira, de Souza, and Moraes Brazilian Journal of Microbiology, vol. 35, no 1-2, 1-21 ---- Here we are sticking with Multidrug resistance protein A [corresponds to the membrane fustion protein] and Multidrug resistance protein B [corresponds to the IM] | ||||||||||||
