Subsystem: Methionine Biosynthesis

This subsystem's description is:

Methionine and cysteine are the two sulfur-containing amino acids, and cysteine biosynthesis constitutes the primary pathway for incorporation of organic sulfur into cellular components. Cysteine serves as a precursor for methionine biosynthesis via the Transsulfuration pathway. Alternative pathway for methionine biosynthesis, the Sulfhydrylation pathway, use inorganic sulfur instead of cysteine. In addition to its general function as a component of proteins, methionine is specifically required for translation initiation and is crucial for a variety of methyltransferase reactions, both as a precursor of S-Adenosyl-Methionine (SAM).

Functional variants:

1. as in E. coli. Full Transsulfuration pathway (has CTGS, CTBL) via O-Succinyl-L-Homoserine (has HSST), and with Methionine Transporter.

2. as in Staphylococcus aureus. Full Transsulfuration pathway via O-Acetyl-L-Homoserine (has HSAT), and with Methionine Transporter.

3. Full Sulfhydrylation pathway (has AHSH) via O-Acetyl-L-Homoserine, and with Methionine Transporter.

4. as in Streptococcus spp. Full Sulfhydrylation pathway via O-Succinyl-L-Homoserine, and with Methionine Transporter.

5. as in Listeria spp. Both Sulfhydrylation and Transsulfuration pathways via O-Acetyl-L-Homoserine, and with Methionine Transporter.

6. as in Clostridium acetobutylicum. Both Sulfhydrylation and Transsulfuration pathways via O- Succinyl -L-Homoserine, and with Methionine Transporter.

7. as in plants. Full Transsulfuration pathway via O- Phospho -L-Homoserine (has HK).

8. as in Enterococcus faecalis. no de novo pathway, with Methionine Transporter

9. unknown pathway

10. as in Bacillus cereus. Both Sulfhydrylation and Transsulfuration pathways via O- Succinyl -L-Homoserine or O-Acetyl-L-Homoserine (has both HSST and HSAT), and with Methionine Transporter.

For more information, please check out the description and the additional notes tabs, below

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