Subsystem: MazEF toxin-antitoxing (programmed cell death) system

This subsystem's description is:

MazF, ChpB, PemK and YdcE are endoribonuclease that inactivate cellular mRNAs by cleaving them at specific sites.
MazE, ChpS, PemI and YdcD are labile inhibitors of the corresponding endonucleases.
Because the inhibitors ("anittoxins") are labile, they must be constantly expressed, or their corresponding endonuclease ("toxin") will kill the cell.

For more information, please check out the description and the additional notes tabs, below

Literature ReferencesThe Bacillus subtilis ydcDE operon encodes an endoribonuclease of the MazF/PemK family and its inhibitor. Pellegrini O Molecular microbiology 2005 Jun15882409
The discovery of mRNA interferases: implication in bacterial physiology and application to biotechnology. Inouye M Journal of cellular physiology 2006 Dec17001682
Ribonucleases in bacterial toxin-antitoxin systems. Cook GM Biochimica et biophysica acta 2013 Jun-Jul23454553
DiagramFunctional RolesSubsystem SpreadsheetDescriptionAdditional Notes 

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Group Alias
Abbrev.Functional RoleReactionsScenario ReactionsGOLiterature
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Taxonomy Pattern 
Organism 
Domain
Variant [?] 
active
MazEMazFChpSChpBPemIPemKYdcDYdcE
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MazF, ChpB, PemK and YdcE are endoribonuclease that inactivate cellular mRNAs by cleaving them at specific sites.
MazE, ChpS, PemI and YdcD are labile inhibitors of the corresponding endonucleases.
Because the inhibitors ("anittoxins") are labile, they must be constantly expressed, or their corresponding endonuclease ("toxin") will kill the cell.
ChpB is also called ChpBK
ChpS is also called ChpBI (and was originally published as ChpA)