Subsystem: MazEF toxin-antitoxing (programmed cell death) system
This subsystem's description is:
MazF, ChpB, PemK and YdcE are endoribonuclease that inactivate cellular mRNAs by cleaving them at specific sites.
MazE, ChpS, PemI and YdcD are labile inhibitors of the corresponding endonucleases.
Because the inhibitors ("anittoxins") are labile, they must be constantly expressed, or their corresponding endonuclease ("toxin") will kill the cell.
For more information, please check out the description and the additional notes tabs, below
| Literature References | The Bacillus subtilis ydcDE operon encodes an endoribonuclease of the MazF/PemK family and its inhibitor. Pellegrini O Molecular microbiology 2005 Jun | 15882409 | The discovery of mRNA interferases: implication in bacterial physiology and application to biotechnology. Inouye M Journal of cellular physiology 2006 Dec | 17001682 | Ribonucleases in bacterial toxin-antitoxin systems. Cook GM Biochimica et biophysica acta 2013 Jun-Jul | 23454553 |
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| Diagram | Functional Roles | Subsystem Spreadsheet | Description | Additional Notes | |||||||||
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MazF, ChpB, PemK and YdcE are endoribonuclease that inactivate cellular mRNAs by cleaving them at specific sites. MazE, ChpS, PemI and YdcD are labile inhibitors of the corresponding endonucleases. Because the inhibitors ("anittoxins") are labile, they must be constantly expressed, or their corresponding endonuclease ("toxin") will kill the cell. ChpB is also called ChpBK ChpS is also called ChpBI (and was originally published as ChpA) | |||||||||||||
