Subsystem: MazEF toxin-antitoxing (programmed cell death) system

This subsystem's description is:

MazF, ChpB, PemK and YdcE are endoribonuclease that inactivate cellular mRNAs by cleaving them at specific sites.
MazE, ChpS, PemI and YdcD are labile inhibitors of the corresponding endonucleases.
Because the inhibitors ("anittoxins") are labile, they must be constantly expressed, or their corresponding endonuclease ("toxin") will kill the cell.

For more information, please check out the description and the additional notes tabs, below

DiagramFunctional RolesSubsystem SpreadsheetDescriptionAdditional Notes 

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Group Alias
Abbrev.Functional RoleReactionsScenario ReactionsGOLiterature
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Taxonomy Pattern 
Organism 
Domain
Variant [?] 
active
MazEMazFChpSChpBPemIPemKYdcDYdcE
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MazF, ChpB, PemK and YdcE are endoribonuclease that inactivate cellular mRNAs by cleaving them at specific sites.
MazE, ChpS, PemI and YdcD are labile inhibitors of the corresponding endonucleases.
Because the inhibitors ("anittoxins") are labile, they must be constantly expressed, or their corresponding endonuclease ("toxin") will kill the cell.
ChpB is also called ChpBK
ChpS is also called ChpBI (and was originally published as ChpA)