Subsystem: Mannitol Utilization

This subsystem's description is:

********VARIANT CODES:*************

1.0 the presence of complete mannitol operon ( as in E. coli);

1.x - some gene is missing in the pathway

2.0 - Alternate route of Mannitol utilization (as in Shewanella frigidimarina)

****In E. coli:*****

The mtl operon in E. coli consists of the mtlA, mtlR, and mtlD genes that encode the mannitol transporter (enzyme IICBA_mtl), a transcriptional regulator, and mannitol-1-phosphate dehydrogenase, respectively, and that in B. stearothermophilus comprises four genes: mtlA (enzyme IICB_mtl), mtlR, mtlF (enzyme IIA_mtl), and mtlD.

****In B. subtilis:******

The B. subtilis mtl operon consists of only the mtlA (enzyme IICBAmtl) and mtlD genes, and the operon does not contain a gene for a transcriptional regulator. However, the gene ydaA, which was recently renamed mtlR and which is homologous to the mtlR genes of E. coli and B. stearothermophilus, is located 14.4 kb down stream from the mtl operon.
It was determined (ref.1) that MtlR in B. subtilis is an activator of the mtl operon, although mtlR is located 14.4 kb downstream from the operon.

Almost all of the genes for the regulator of mannitol-specific PTS in bacteria, except for B. subtilis, are included in the mtl operon as it is in E. coli, B. stearothermophilus, and Streptococcus mutans, and MtlR is essential for expression of the mtl operons. To confer an advantage in the proliferation of B. subtilis, the location of mtlR at a distance from the mtl operon may have been acquired by chromosomal rearrangement during evolution.

For more information, please check out the description and the additional notes tabs, below

Literature ReferencesMannitol-1-phosphate dehydrogenase (MtlD) is required for mannitol and glucitol assimilation in Bacillus subtilis: possible cooperation of mtl and gut operons. Watanabe S Journal of bacteriology 2003 Aug12897001
Molecular analysis of the mannitol operon of Clostridium acetobutylicum encoding a phosphotransferase system and a putative PTS-modulated regulator. Behrens S Microbiology (Reading, England) 2001 Jan11160802
Novel phosphotransferase system genes revealed by genome analysis - the complete complement of PTS proteins encoded within the genome of Bacillus subtilis. Reizer J Microbiology (Reading, England) 1999 Dec10627040
DiagramFunctional RolesSubsystem SpreadsheetDescriptionAdditional NotesScenarios 

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Group Alias
Abbrev.Functional RoleReactionsScenario ReactionsGOLiterature

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