Subsystem: Lysozyme inhibitors

This subsystem's description is:

A group of genes responsible for the production of lysozyme inhibitors present in many Proteobacteria.

For more information, please check out the description and the additional notes tabs, below

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IvyPliCMliCEspC
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A group of genes responsible for the production of lysozyme inhibitors present in many Proteobacteria.
Lysozymes (EC 3.2.1.17) hydrolyse the β-(1,4) glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine in peptidoglycan, the major cell wall polymer in the Bacteria. Lysozymes are implicated in defensive and offensive bactericidal systems in a wide range of taxonomically diverse organisms including fungi, protozoa, plants, invertebrate and vertebrate animals and even bacteriophages. Bacteria have in turn evolved mechanisms to evade or subvert this threat, most commonly by peptidoglycan modification. A different bacterial strategy to evade the bactericidal action of lysozyme is the production of lysozyme inhibitors.
The location of the bacterial lysozyme inhibitors either in the periplasm (Inhibitor of vertebrate lysozyme precursor Ivy and Periplasmic lysozyme inhibitor of c-type lysozyme PliC) or anchored to the luminal face of the outer membrane (Membrane-bound lysozyme inhibitor of c-type lysozyme MliC) is consistent with a role in protecting peptidoglycan from hydrolysis by exogenous lysozymes.
Regulation of expression of the lysozyme inhibitors is regulated by the Rcs phosphorelay signal transduction system.