Subsystem: Lysine degradation

This subsystem's description is:

At least 9 pathways exist for the degradation of lysine in mammals, plants, bacteria and fungi. The initial products of lysine degradation in these pathways include: L-saccharopine in mammals and plants; beta-L-lysine, 5-aminovaleramide, N6-hydroxylysine, cadaverine, and alpha-aminoadipate-delta-semialdehyde in bacteria; and alpha -aminoadipate-delta-semialdehyde, D-lysine, N6-acetyl-L-lysine, and 6-amino-2-oxocaproic acid in yeasts and fungi.

====Variant codes:==========

1.0 - Cadaverine pathway (from L-lysine to {delta}-aminovalerate via cadaverine/1-piperidine);

2.0 - AMV (aminovalerate) pathway (from L-lysine to glutaric acid);

3.0 - AMA (aminoadipate ) pathway (from D-lysine to 2-aminoadipate);

4.0 - AMV + AMA (as in Pseudomonas putida );

4.1 - AMV + AMA + Cadaverine pathway(as in Pseudomonas aeruginosa );

5.0 - Lysine fermentation ( as in Fusobacterium nucleatum);

6.0 - Eukaryotic pathway ( as in Saccharomyces cerevisiae).

For more information, please check out the description and the additional notes tabs, below

Literature ReferencesCrystal structures of Delta1-piperideine-2-carboxylate/Delta1-pyrroline-2-carboxylate reductase belonging to a new family of NAD(P)H-dependent oxidoreductases: conformational change, substrate recognition, and stereochemistry of the reaction. Goto M The Journal of biological chemistry 2005 Dec 916192274
Pathway of lysine degradation in Fusobacterium nucleatum. Barker HA Journal of bacteriology 1982 Oct6811551
The putative malate/lactate dehydrogenase from Pseudomonas putida is an NADPH-dependent delta1-piperideine-2-carboxylate/delta1-pyrroline-2-carboxylate reductase involved in the catabolism of D-lysine and D-proline. Muramatsu H The Journal of biological chemistry 2005 Feb 1815561717
Identification of the last unknown genes in the fermentation pathway of lysine. Kreimeyer A The Journal of biological chemistry 2007 Mar 917166837
Multiple and interconnected pathways for L-lysine catabolism in Pseudomonas putida KT2440. Revelles O Journal of bacteriology 2005 Nov16237033
DiagramFunctional RolesSubsystem SpreadsheetDescriptionAdditional NotesScenarios 

Showing colors for genome: Staphylococcus aureus subsp. aureus str. Newman ( 426430.8 ), variant code 1.0

This diagram is not scaled.


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