Subsystem: Lactose and Galactose Uptake and Utilization

This subsystem's description is:

Staphylococcus aureus cannot hydrolyse lactose directly. Instead, it has an enzyme, phospho-beta-galactosidase, that hydrolytically cleaves the phosphorylated derivative of lactose into glucose and galactose-6-phosphate. Staphylococcus aureus transports lactose and galactose across the membrane and into the cell by a phosphoenolpyruvate dependent phosphotransferase system, during which, lactose and galactose are phosphorylated respectively to lactose-6-phosphate, and galactose-6-phosphate.

Staphylococcus aureus degrades D-galactose-6-phosphate via the D-tagatose-6-phosphate pathway, a series of three reactions, analogous to the first three reactions of the Embden-Meyerhof pathway for D-glucose-6-phosphate metabolism. The enzymes catalyzing the reactions in the D-tagatose-6-phosphate pathway:
D-galactose-6-phosphate isomerase,
D-tagatose-6-phosphate kinase,
and D-tagatose-1,6-diphosphate aldolase
were partially purified and characterized.


=========Variant codes:=============

1.0 - Lactose and galactose uptake by lactose permease and degradation (lac operon + gal);

2.0 - uptake and degradation of lactose by Staphylococcus way (cleaves the phosphorylated derivative of lactose into glucose and galactose-6-phosphate);

3.0 - lactose and galactose uptake and degradation in both ways (Streptococcus pneumoniae);

4.0 - Galactose uptake and degradation only

W - Lactose and galactose uptake by lactose permease and degradation (lac operon + gal) (with some to many genes missing);

X - LacC, *LacZ, GalE only;

Y - 1 or 2 genes missing for lactose and galactose utilization;

Z - Tagatose utilization pathway only.

For more information, please check out the description and the additional notes tabs, below

DiagramFunctional RolesSubsystem SpreadsheetDescriptionAdditional NotesScenarios 

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Group Alias
Abbrev.Functional RoleReactionsScenario ReactionsGOLiterature
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