Subsystem: L-fucose utilization and AldA biosynthesis

This subsystem's description is:

Original Description (by Rodionov)

The well studied L-fucose utilization pathway in Escherichia coli include L-fucose uptake by FucP permease, isomerization by FucI isomerase, phosphorylation by the FGGY family kinase FucK and breakdown by FucA aldolase to produce glycerone-P and L-lactaldehyde. In E.coli lactaldehyde is converted to L-1,2-propanediol by lactaldehyde reductase FucO.
We predicted novel route of lactaldehyde utilization by a dehydrogenase gene (FucZ functional role), which could be shared by L-rhamnose pathway (RhaZ functional role). FucZ and RhaZ are the same functional roles that could be involved in conversion of lactaldehyde to L-lactate to finish the rhamnose pathway. The species that lack FucO and these novel roles (like Haemophilius) are most likely use intrinsic aldehyde dehydrogenases (aldA or aldB) for this final step of rhamnose catabolism.

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Literature ReferencesA genetic locus necessary for rhamnose uptake and catabolism in Rhizobium leguminosarum bv. trifolii. Richardson JS Journal of bacteriology 2004 Dec15576793
Metabolism of L-fucose and L-rhamnose in Escherichia coli: aerobic-anaerobic regulation of L-lactaldehyde dissimilation. Baldomà L Journal of bacteriology 1988 Jan3275622
DiagramFunctional RolesSubsystem SpreadsheetDescriptionAdditional Notes 

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