Subsystem: Isoleucine degradation
This subsystem's description is:
The Isoleucine degradation pathway is widely spread, and is found in many microorganisms, higher plants, and animals, including mammals.
The catabolism of L-isoleucine begins with its transamination to 2-keto-3-methyl-valerate , followed by oxidative decarboxylation to S-2-methyl-butyryl-CoA . S-2-methyl-butyryl-CoA then undergoes a four-step oxidation process, involving dehydrogenation to tiglyl-CoA , hydration to 2-methyl-3-hydroxybutyryl-CoA , dehydrogenation to 2-methylacetoacetyl-CoA , and finally a thioester hydrolysis forming acetyl-CoA and propionyl-CoA.
1.0 - All genes of Isoleucine degradation pathway are present;
1.x - Isoleucine degradation pathway with missing genes(often they are the components of Branched-chain alpha-keto acid dehydrogenase complex and there is a annotation problem - conflict with other dehydrogenase complexes)
2.0 - 2-Methylbutyryl-CoA precursor goes straight to Branched-chain fatty acids biosynthesis ( as in Listeria)
-1 - No Isoleucine degradation pathway
For more information, please check out the description and the additional notes tabs, below
|Literature References||Role of bkdR, a transcriptional activator of the sigL-dependent isoleucine and valine degradation pathway in Bacillus subtilis. Debarbouille M Journal of bacteriology 1999 Apr||10094682|
|Diagram||Functional Roles||Subsystem Spreadsheet||Description||Additional Notes||Scenarios|