Subsystem: Isoleucine degradation

This subsystem's description is:

The Isoleucine degradation pathway is widely spread, and is found in many microorganisms, higher plants, and animals, including mammals.

The catabolism of L-isoleucine begins with its transamination to 2-keto-3-methyl-valerate , followed by oxidative decarboxylation to S-2-methyl-butyryl-CoA . S-2-methyl-butyryl-CoA then undergoes a four-step oxidation process, involving dehydrogenation to tiglyl-CoA , hydration to 2-methyl-3-hydroxybutyryl-CoA , dehydrogenation to 2-methylacetoacetyl-CoA , and finally a thioester hydrolysis forming acetyl-CoA and propionyl-CoA.

======VARIANT CODES:=============================

1.0 - All genes of Isoleucine degradation pathway are present;

1.x - Isoleucine degradation pathway with missing genes(often they are the components of Branched-chain alpha-keto acid dehydrogenase complex and there is a annotation problem - conflict with other dehydrogenase complexes)

2.0 - 2-Methylbutyryl-CoA precursor goes straight to Branched-chain fatty acids biosynthesis ( as in Listeria)

-1 - No Isoleucine degradation pathway

For more information, please check out the description and the additional notes tabs, below

DiagramFunctional RolesSubsystem SpreadsheetDescriptionAdditional NotesScenarios 

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Abbrev.Functional RoleReactionsScenario ReactionsGOLiterature

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