Subsystem: Heme biosynthesis orphans

This subsystem's description is:

For more information, please check out the description and the additional notes tabs, below

DiagramFunctional RolesSubsystem SpreadsheetAdditional Notes 

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Group Alias
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Taxonomy Pattern 
Organism 
Domain
Variant [?] 
active
NirSNirDNirGNirLNirHNirjNirD2NirG2NirL2NirH2NirDGNirLHNirJ2
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This is an attempt to gather some of the genes associated with heme biosynthesis,
which are not in other subsystems, and that create paralogy problems.

The first group are genes in heme d1 synthesis. They are required.

The following 2 groups are genes often clusted with heme or porphorin synthesis genes,
but which do not seem to have quite as well defined a function.

Variants:

1 = NirDGLH(J) - this is heme d1 synthesis (indicated by presence of NirS)
2 = NirD2,G2,L2,H2,(J) - these are all Halophiles, and look very much like heme d1 genes
3 = NirDG,NirLH - these clearly predate the NirD-NirG and NirL-NirH divergences

NirJ and NirJ2 are radical-SAM proteins that are often confused with PqqE (which is why
this all got started).###############################
LITERATURE