Subsystem: Gentisate degradation

This subsystem's description is:

Xylenols and cresols can be degraded via the gentisate pathway.Gentisate 1,2-dioxygenase (GDO; EC 1.13.11.4) is required to consider this pathway as a functional in particular bacteria.he hbzE gene was found to be part of a cluster of nine genes including the putative regulatory gene designated hbzR, which encodes an LysR-type regulator and is divergently transcribed from the other genes of the hbzHIJKLFED cluster.Gentisate 1,2-dioxygenase I (GDO-I) is encoded by xlnE. However, GDO-II was unable to utilize gentisate that is substituted at the carbon-4 position, unlike GDO-I which had broader substrate specificity.The hbzE-encoded GDO-II shared higher sequence identities (53%) with GDOs from Ralstonia sp. U2 and Polaromonas naphthalenivorans CJ2, compared with only 35% identity with the xlnE-encoded GDO-I. The hbzE gene was found to be part of a cluster of nine genes including the putative regulatory gene designated hbzR, which encodes an LysR-type regulator and is divergently transcribed from the other genes of the hbzHIJKLFED cluster.

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DiagramFunctional RolesSubsystem SpreadsheetDescriptionAdditional Notes 

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