Subsystem: Fructoselysine (Amadori product) utilization pathway

This subsystem's description is:

The metabolism of the glycation product fructose-epsilon-lysine in Escherichia coli involves its ATP-dependent phosphorylation by a specific kinase (FrlD), followed by the conversion of fructoselysine 6-phosphate into glucose 6-phosphate and lysine by fructoselysine-6-phosphate deglycase (FrlB), which is distantly related to the isomerase domain of glucosamine-6-phosphate synthase.

The frl (fructoselysine) operon encodes fructoselysine 6-kinase and fructoselysine 6-phosphate deglycase, allowing the conversion of fructoselysine into glucose 6-phosphate and lysine. The third enzyme encoded by this operon catalyses the metal-dependent reversible interconversion of fructoselysine with its C-3 epimer, psicoselysine.

For more information, please check out the description and the additional notes tabs, below

Literature ReferencesIdentification of glucoselysine-6-phosphate deglycase, an enzyme involved in the metabolism of the fructation product glucoselysine. Wiame E The Biochemical journal 2005 Dec 116153181
Identification of a pathway for the utilization of the Amadori product fructoselysine in Escherichia coli. Wiame E The Journal of biological chemistry 2002 Nov 812147680
DiagramFunctional RolesSubsystem SpreadsheetDescriptionAdditional Notes 

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FrlDFrlBFrlCFrlRFrlA
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The metabolism of the glycation product fructose-epsilon-lysine in Escherichia coli involves its ATP-dependent phosphorylation by a specific kinase (FrlD), followed by the conversion of fructoselysine 6-phosphate into glucose 6-phosphate and lysine by fructoselysine-6-phosphate deglycase (FrlB), which is distantly related to the isomerase domain of glucosamine-6-phosphate synthase.

The frl (fructoselysine) operon encodes fructoselysine 6-kinase and fructoselysine 6-phosphate deglycase, allowing the conversion of fructoselysine into glucose 6-phosphate and lysine. The third enzyme encoded by this operon catalyses the metal-dependent reversible interconversion of fructoselysine with its C-3 epimer, psicoselysine.
======REFERENCES: ==============

1. Wiame E, Delpierre G, Collard F, Van Schaftingen E.. Identification of a pathway for the utilization of the Amadori product fructoselysine in Escherichia coli.J Biol Chem. 2002 Nov 8;277(45):42523-9. PMID: 12147680

2. Wiame E, Lamosa P, Santos H, Van Schaftingen E.. Identification of glucoselysine-6-phosphate deglycase, an enzyme involved in the metabolism of the fructation product glucoselysine. Biochem J. 2005 Dec 1;392(Pt 2):263-9. PMID: 16153181

3. Wiame E, Van Schaftingen E. Fructoselysine 3-epimerase, an enzyme involved in the metabolism of the unusual Amadori compound psicoselysine in Escherichia coli. Biochem J. 2004 Mar 15;378(Pt 3):1047-52. PMID: 14641112

4. Gemayel R, Fortpied J, Rzem R, Vertommen D, Veiga-da-Cunha M, Van Schaftingen E. Many fructosamine 3-kinase homologues in bacteria are ribulosamine/erythrulosamine 3-kinases potentially involved in protein deglycation. FEBS J. 2007 Sep;274(17):4360-74. PMID: 17681011