Subsystem: Fosfomycin resistance

This subsystem's description is:

Fosfomycin resistance protein FosA
Fosfomycin resistance protein FosB
Fosfomycin resistance protein FosX

FosA catalyzes the addition of glutathione to C1 of the oxirane.
FosB catalyzes the addition of L-cysteine to C1 of the oxirane.
FosX catalyzes the Mn(II)-dependent addition of water to C1 of the oxirane.

For more information, please check out the description and the additional notes tabs, below

Literature ReferencesFosfomycin resistance proteins: a nexus of glutathione transferases and epoxide hydrolases in a metalloenzyme superfamily. Rigsby RE Methods in enzymology 200516399398
Mechanistic diversity of fosfomycin resistance in pathogenic microorganisms. Fillgrove KL Journal of the American Chemical Society 2003 Dec 2414677948
DiagramFunctional RolesSubsystem SpreadsheetDescription 

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Group Alias
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Taxonomy Pattern 
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FosAFosBFosX
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Fosfomycin resistance protein FosA
Fosfomycin resistance protein FosB
Fosfomycin resistance protein FosX

FosA catalyzes the addition of glutathione to C1 of the oxirane.
FosB catalyzes the addition of L-cysteine to C1 of the oxirane.
FosX catalyzes the Mn(II)-dependent addition of water to C1 of the oxirane.