Subsystem: DNA replication, archaeal

This subsystem's description is:

For more information, please check out the description and the additional notes tabs, below

DiagramFunctional RolesSubsystem SpreadsheetAdditional Notes 

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Group Alias
Abbrev.Functional RoleReactionsScenario ReactionsGOLiterature
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Taxonomy Pattern 
Organism 
Domain
Variant [?] 
active
ORCCDC6MCMRFAPri-1Pri-2RFC1RFC2PCNADNAP-1DNAP-2LDNAP-2SRNaseHIIligaseFEN
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Sketch of steps in DNA replication:

ORC/CDC6 protein binds at origin of replication
MCM protein is recuited to site, forming a hexameric ring around DNA strand
MCM unwinds DNA
Primase synthesizes RNA primer
Replication factor C binds and recruits PCNA
PCNA makes a "sliding clamp" for DNA polymerase
DNA polymerase synthesizes new strand

RNase H removes primers
RNA ligase seals nicks