Subsystem: D-galactonate catabolism

This subsystem's description is:

D-Galactonate is catabolized to give pyruvate and glyceraldehyde-3-phosphate by a pathway that involves the sequential reactions of galactonate dehydratase (GalD), 2-keto-3-deoxy-galactonate kinase (DgoK), and 6-phospho-2-keto-3-deoxy-galactonate aldolase (DgoA).
Only GalD was characterized experimentally.
Uptake of D-galactonate is believed to be mediated by DgoT in E.coli.

For more information, please check out the description and the additional notes tabs, below

Literature ReferencesA functionally diverse enzyme superfamily that abstracts the alpha protons of carboxylic acids. Babbitt PC Science (New York, N.Y.) 1995 Feb 247855594
Pathway for D-galactonate catabolism in nonpathogenic mycobacteria. SzumiƂo T Journal of bacteriology 1981 Oct7287628
DiagramFunctional RolesSubsystem SpreadsheetDescriptionAdditional NotesScenarios 

Oops! We thought there was a diagram here, but we can't find it. Sorry

Group Alias
Abbrev.Functional RoleReactionsScenario ReactionsGOLiterature
SubsetsColoring
collapsed
expanded


  
display  items per page
«first  «prevdisplaying 1 - 452 of 452next»  last»
Taxonomy Pattern 
Organism 
Domain
Variant [?] 
active
DgoTGalDDgoKDgoADgoRDGR1
«first  «prevdisplaying 1 - 452 of 452next»  last»
D-Galactonate is catabolized to give pyruvate and glyceraldehyde-3-phosphate by a pathway that involves the sequential reactions of galactonate dehydratase (GalD), 2-keto-3-deoxy-galactonate kinase (DgoK), and 6-phospho-2-keto-3-deoxy-galactonate aldolase (DgoA).
Only GalD was characterized experimentally.
Uptake of D-galactonate is believed to be mediated by DgoT in E.coli.
Open problems:
In E.coli, D-galactonate is taken up using specific permease. However in other species, it could be produced from D-galactose by galactose-1-dehydrogenase (EC 1.1.1.48) and in some organisms may require also 1,4-lactonase. In a-proteobacteria, DgoK and DgoA are present but homologous GalD is absent. In clusters with dgoK-dgoA there are numerouse genes that could supplement this gap:
1. putative dehydratase from the IlvD/Edd family;
2. Short chain dehydrogenase/reductase (similar to 3-oxoacyl-(acyl carrier protein) reductase)
3. galactose-1-dehydrogenase (EC 1.1.1.48)(pointing out for using D-galactose as a source)
4. Gluconolactonase (EC 3.1.1.17)
5. transcriptional regulator from the IclR family (predicted regulator of dgo genes)


References:
Science. 1995 Feb 24;267(5201):1159-61. PMID: 7855594
Szumilo T. J Bacteriol. 1981 Oct;148(1):368-70 (PMID: 7287628)

Currently selected organism: Escherichia coli 2731150 (open scenarios overview page for organism)