Subsystem: Competence or DNA damage-inducible protein CinA and related protein families

This subsystem's description is:

This subsystem has been encoded to find home for diverse members of the CinA protein family. The prototype of the family, Streptococcal Competence/damage-inducible protein CinA (Martin et al., 1995), is coexpressed with RecA in many Gram(+) species at the onset of competence and also in cells treated with mitomycin C, indicating that this operon could also be DNA damage inducible (Martin et al., 1995). Although the function of CinA homologs in Gram(-) organisms have not been studied, they are included in this SS as well. They are not co-localized with RecA generally.

Bona fide CinA protein contains 2 domains, annotated here as:
-N: Molybdopterin binding motif, CinA N-terminal domain
-C: C-terminal domain of CinA type S (YgaD in EC)
-C: C-terminal domain of CinA type E (YfaY in EC)

However, each of these domains can occur as stand-alone proteins, or in fusions with other types of domains as well. The latter are included in this SS as AUX Roles (along with hypothetical families, that CinA domains tend to co-localize with):

>> CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (EC -> strong colocalization + fusion in Slakia & Eggerthella: fig|471855.4.peg.14, fig|479437.4.peg.2890

>> Phosphatidylglycerophosphatase A (EC -> strong colocalization
>> RecA protein -> strong colocalization
>> DNA mismatch repair protein MutL
>> FMN adenylyltransferase, type 2 eukaryotic -> fusion
>> FIG002344: Hydrolase (HAD superfamily)
>> Hsp33 protein with redox-regulated chaperone activity -> fusion in fig|262722.3.peg.310)
>> Strange 3-domain fusion in Cryptobacterium curtum -> fig|469378.4.peg.433 (assembly mistake?)
>> hypotheticals

YbjD homologs:
The YbjD protein family contains 2 hypothetical domains: the C-terminal TOPRIM (topoisomerase-primase) nucleotidyl transferase/hydrolase domain and the N-terminal ABC-type ATPase domain. The YbjD family shares this architecture with a large number of bacterial and archaeal proteins, often encoded by plasmids, prophages and phages. For example, the bacteriophage P2 protein OLD (=overcome lysogenization defect), which has DNase as well as RNase activity (PMID: 9722641); or subgroup “FIG131328: Predicted ATP-dependent endonuclease of the OLD family”, encoded in Subsystem CBSS-1496.1.peg.2937.
Since overall homology among the members of this supefamiliy is rather low, only the clear homologs of the E. coli protein YbjD (b0876) are associated with this Subsystem


Martin B, García P, Castanié MP, Claverys JP. 1995. The recA gene of Streptococcus pneumoniae is part of a competence-induced operon and controls lysogenic induction. Mol Microbiol, 15: 367-379

For more information, please check out the description and the additional notes tabs, below

DiagramFunctional RolesSubsystem SpreadsheetDescription 

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Group Alias
Abbrev.Functional RoleReactionsScenario ReactionsGOLiterature

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