Subsystem: Coenzyme B12 biosynthesis
This subsystem's description is:
Cobalamin (CBL), along with chlorophyll, haem, sirohaem and coenzyme F430, constitute a class of the most structurally complex cofactors synthesized by bacteria. The distinctive feature of these cofactors is their tetrapyrrole-derived framework with a centrally chelated metal ion (cobalt, magnesium, iron, or nickel). Methylcobalamin and Ado-CBL, two derivatives of vitamin B12 (cyanocobalamin) with different upper axial ligands, are essential cofactors for several important enzymes which catalyze a variety of transmethylation and rearrangement reactions. Among the most prominent vitamin B12-dependent enzymes in bacteria and archaea are the methionine synthase isozyme MetH from enteric bacteria; the ribonucleotide reductase isozyme NrdJ from deeply rooted eubacteria and archaea; diol dehydratases and ethanolamine ammonia lyase from enteric bacteria involved in anaerobic glycerol, 1,2-propanediol and ethanolamine fermentation; glutamate and methylmalonyl-CoA mutases from clostridia and streptomycetes; and various CBL-dependent methyltransferases from methane-producing archaea (1, 2, 3, 4, 5).
Zhang Y, Rodionov DA, Gelfand MS, Gladyshev VN. Comparative genomic analyses of nickel, cobalt and vitamin B12 utilization. BMC Genomics. 2009 Feb 10;10:78.
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|Literature References||Comparative genomic analyses of nickel, cobalt and vitamin B12 utilization. Zhang Y BMC genomics 2009 Feb 10||19208259|
|Diagram||Functional Roles||Subsystem Spreadsheet||Description||Additional Notes||Scenarios|