Subsystem: CBSS-56780.10.peg.1536

This subsystem's description is:

part of phoH -associated cluster

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part of phoH -associated cluster
J Bacteriol. 2009 Jan 30. [Epub ahead of print]Click here to read Links
YbeY - a heat shock protein involved in translation in Escherichia coli.
Rasouly A, Schonbrun M, Shenhar Y, Ron EZ.

Department of Molecular Microbiology and Biotechnology, The George S. Wise Faculty of Life Sciences, Tel-Aviv University, Tel-Aviv 69978, Israel.

Here we provide evidence that YbeY - a conserved heat shock protein with unknown function - is involved in the translation process. Deletion mutants of ybeY are temperature sensitive and have a significantly reduced thermo-tolerance. Nonetheless, there appears to be no damage of the protein quality control of mature polypeptides, as the levels of chaperones and proteases are normal and there is no accumulation of aggregates. Rather, the mutation results in a significant reduction in the level of polysomes and upon a shift to restrictive temperatures (42 degrees C) there is an immediate and severe slow-down of translation. Taken together, the data indicate that YbeY is an important factor for bacterial translation even at 37 degrees C, but becomes essential at high temperatures.