Subsystem: Bacitracin Stress Response

This subsystem's description is:

The specific ABC transporters and their associated genes induced in response to bacitracin, a cyclic dodecylpeptide antibiotic, non-ribosomally synthesized by B. licheniformis and some strains of B. subtilis, that inhibits cell wall biosynthesis by binding very tightly to the long-chain undecaprenyl pyrophosphate.

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Literature ReferencesBacitracin sensing in Bacillus subtilis. Rietkötter E Molecular microbiology 2008 May18394148
Cell wall stress responses in Bacillus subtilis: the regulatory network of the bacitracin stimulon. Mascher T Molecular microbiology 2003 Dec14651641
DiagramFunctional RolesSubsystem SpreadsheetDescriptionAdditional Notes 

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The specific ABC transporters and their associated genes induced in response to bacitracin, a cyclic dodecylpeptide antibiotic, non-ribosomally synthesized by B. licheniformis and some strains of B. subtilis, that inhibits cell wall biosynthesis by binding very tightly to the long-chain undecaprenyl pyrophosphate.
Bacitracin leads to the transcriptional induction of numerous genes controlled by at least two alternative σ factors and three two-component regulatory systems. These three two-component systems are located next to target genes strongly induced by bacitracin.
The corresponding histidine kinases lack about 100 amino acids in their extracellular sensing domain, which is almost entirely buried in the cytoplasmic membrane.