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Subsystem: Bacitracin Stress Response

This subsystem's description is:

The specific ABC transporters and their associated genes induced in response to bacitracin, a cyclic dodecylpeptide antibiotic, non-ribosomally synthesized by B. licheniformis and some strains of B. subtilis, that inhibits cell wall biosynthesis by binding very tightly to the long-chain undecaprenyl pyrophosphate.

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Diagram	Functional Roles	Subsystem Spreadsheet	Description	Additional Notes
Oops! We thought there was a diagram here, but we can't find it. Sorry Group Alias Abbrev. Functional Role Reactions Scenario Reactions GO Literature Subsets Coloring collapsed expanded do not color by cluster by attribute: BS_essential_Kobayashi EC_contribute_to_fitness EC_essential_Blattner EC_essential_Keio EC_essential_Shigen Essential_Gene_Sets_Bacterial HP_candidate_essential_Salama MG_essential_Hutchison_2006 MT_contribute_to_fitness_Rubin PA_candidate_essential_Jacobs PA_essential_PA14_PAO1_Liberati SA_essential_Forsyth SA_essential_Ji SA_essential_merged_Forsyth_and_Ji SP_essential_merged SP_essential_Song SP_essential_Thanassi ST_essential_Knuth CELLO cell_surface established_antibiotic_inhibitor established_antibiotic_target GENE3D iedb_epitopelinearsequence iedb_epitopename in_phage isoelectric_point microarray_sigmaB_regulon molecular_weight mouse_passage_in_THY_18_hours_change PANTHER PDB Phobius PRINTS PROFILE PSORT PSORT_score secreted_protein_signal SignalP similar_to_human SMART SSF structure TIGRFAMs toxin Vibrio_Fe-regulated_Mey2005 Vibrio_Fur-regulated_Mey2005 virulence_associated virulence_associated_by_adhesion_properties_of_mutants virulence_associated_by_evolution_of_epidemic_microarray virulence_associated_by_mutagenesis_and_nematode_killing virulence_associated_by_Rot_expression_analysis virulence_associated_by_screening_mutants_in_murine_model virulence_associated_by_site_specific_mutation virulence_associated_by_vaccination    display  items per page «first  «prev displaying 1 - 319 of 319 next»  last» Taxonomy  Pattern  Organism  Domain Variant Variant Codes -1 Subsystem is not present 0 presence unknown * computer assessed variant (not confirmed by annotator) others functional variant [?]  =!= active BceB BceA BceS BceR LiaR LiaS LiaF LiaG LiaH LiaI YvcP YvcQ YvcR YvcS Bacitracin export permease protein BceB Bacitracin export ATP-binding protein BceA Response regulator LiaR Sensor histidine kinase LiaS Transporter LiaF Protein LiaH, similar to phage shock protein A Protein LiaI Two-component response regulator YvcP Two-component sensor kinase YvcQ ABC transporter ATP-binding protein YvcR ABC transporter permease protein YvcS Two-component response regulator BceR Two-component sensor histidine kinase BceS Conserved protein LiaG in B. subtilis in Lia cluster «first  «prev displaying 1 - 319 of 319 next»  last» The specific ABC transporters and their associated genes induced in response to bacitracin, a cyclic dodecylpeptide antibiotic, non-ribosomally synthesized by B. licheniformis and some strains of B. subtilis, that inhibits cell wall biosynthesis by binding very tightly to the long-chain undecaprenyl pyrophosphate. Bacitracin leads to the transcriptional induction of numerous genes controlled by at least two alternative σ factors and three two-component regulatory systems. These three two-component systems are located next to target genes strongly induced by bacitracin. The corresponding histidine kinases lack about 100 amino acids in their extracellular sensing domain, which is almost entirely buried in the cytoplasmic membrane.