Subsystem: Aromatic amino acid interconversions with aryl acids

This subsystem's description is:

For more information, please check out the description and the additional notes tabs, below

DiagramFunctional RolesSubsystem SpreadsheetAdditional Notes 

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Group Alias
Abbrev.Functional RoleReactionsScenario ReactionsGOLiterature
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Taxonomy Pattern 
Organism 
Domain
Variant [?] 
active
ACTLaaACTiorABiorAiorALiorBiorB2paaK
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This SS was started by W.B. Whitman and will be extended by VeronikaV.

Common in anaerobes, this system interconverts aromatic amino acids (try, tyr, and phe) to the aryl acids (indoleacete, hydroxyphenylacetate, and phenylacetate). Used biosynthetically in many methanogens and other organisms, involved in amino acid catabolism in Pyrococcus and others.

See for instance: Porat I, Waters BW, Teng Q, Whitman WB.(2004) Two biosynthetic pathways for aromatic amino acids in the archaeon Methanococcus maripaludis J. Bacteriol. 186:4940-4950.

The entire pathway is:

aryl acid
| + HS-CoA + ATP
|
aryl acid-S-CoA
| + CO2 + Ferredoxin(red)
| IOR
ketoacid
| + glutamate (or some N-donor)
|
amino acid