Subsystem: Aromatic amino acid interconversions with aryl acids
This subsystem's description is:
For more information, please check out the description and the additional notes tabs, below
|Diagram||Functional Roles||Subsystem Spreadsheet||Additional Notes|
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This SS was started by W.B. Whitman and will be extended by VeronikaV.
Common in anaerobes, this system interconverts aromatic amino acids (try, tyr, and phe) to the aryl acids (indoleacete, hydroxyphenylacetate, and phenylacetate). Used biosynthetically in many methanogens and other organisms, involved in amino acid catabolism in Pyrococcus and others.
See for instance: Porat I, Waters BW, Teng Q, Whitman WB.(2004) Two biosynthetic pathways for aromatic amino acids in the archaeon Methanococcus maripaludis J. Bacteriol. 186:4940-4950.
The entire pathway is:
| + HS-CoA + ATP
| + CO2 + Ferredoxin(red)
| + glutamate (or some N-donor)