Subsystem: Arginine Deiminase Pathway

This subsystem's description is:

This pathway is widely distributed among eubacteria and archaea. Genes of the ADI pathway were first characterized in Pseudomonas aeruginosa as the arcDABC operon, encoding an arginine/ornithine antiporter, arginine deiminase, catabolic ornithine carbamoyltransferase, and carbamate kinase, respectively. The major physiological function of this pathway appears to supply ATP under anaerobic conditions. The arc operons from a variety of organisms have also been reported: Lactobacillus sake , B. licheniformis, Clostridium perfringens, Rhizobium etli , Halobacterium salinarium, Oenococcus oeni, and Enterococcus faecalis, and the gene order is quite conserved in different species with some variations. In E. faecalis, the ADI pathway is induced by arginine irrespective of the state of aeration, which is likely the result of a unique regulatory circuit with three different transcriptional regulators encoded in the same locus as the arc genes.

========Variant codes:=========================================================

1.0 - complete Arginine Deiminase System pathway(three enzymes-ArcABC):

1.1 - three enzymes-ArcABC + transporter ArcD

1.2 - three enzymes-ArcABC + regulator (ArcR or ArgR)

1.3 - three enzymes-ArcABC + transporterArcD + regulator(ArcR or ArgR)

x - stands for the absence of one of elements

For more information, please check out the description and the additional notes tabs, below

Literature ReferencesGenetic structure and transcriptional analysis of the arginine deiminase (ADI) cluster in Lactococcus lactis MG1363. Budin-Verneuil A Canadian journal of microbiology 2006 Jul16917516
The Product of arcR, the sixth gene of the arc operon of Lactobacillus sakei, is essential for expression of the arginine deiminase pathway. Zúñiga M Applied and environmental microbiology 2002 Dec12450828
Characterization of the arginine deiminase operon of Streptococcus rattus FA-1. Griswold A Applied and environmental microbiology 2004 Mar15006749
Web linksl-arginine biosynthesis and catabolism
DiagramFunctional RolesSubsystem SpreadsheetDescriptionAdditional Notes 

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Group Alias
Abbrev.Functional RoleReactionsScenario ReactionsGOLiterature

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