Subsystem: Archaeal lipids

This subsystem's description is:

For more information, please check out the description and the additional notes tabs, below

DiagramFunctional RolesSubsystem SpreadsheetAdditional Notes 

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Group Alias
Abbrev.Functional RoleReactionsScenario ReactionsGOLiterature
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Taxonomy Pattern 
Organism 
Domain
Variant [?] 
active
23-dGGGPS3-GGGPSACATDGGGPLRDMATDPM_decarb5PPS4PPS3PPTGPDH6PPPHMG-CoA_redHMP-CoA_synIPP_kinIPDPIIPDPI-FMNMev_kinPM_kinMJ0861
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Archaeal membrane lipids are characterized by (S)-2,3-di-O-geranylgeranylglyceryl phosphate, and variations.

Grochowski, L. L., Xu, H., and White, R. H. 2006. Methanocaldococcus jannaschii uses a modified mevalonate pathway for biosynthesis of isopentenyl diphosphate. J. Bacteriol. 188: 3192-8.
PMID: 16621811


Acetyl-CoA
|
| Acetyl-CoA
|/
| Acetyl-CoA acetyltransferase (EC 2.3.1.9)
|\
| CoA
|
Acetoacetyl-CoA
|
| Acetyl-CoA
|/
| Hydroxymethylglutaryl-CoA synthase (EC 2.3.3.10)
|\
| CoA
|
Hydroxymethylglutaryl-CoA
|
| 2 NADPH
|/
| Hydroxymethylglutaryl-CoA reductase (EC 1.1.1.34)
|\
| 2 NADP+ + CoA
|
Mevalonate
|
| ATP
|/
| Mevalonate kinase (EC 2.7.1.36)
|\
| ADP
|
Mevalonate phosphate
|
| Phosphomevalonate decarboxylase - hypothetical
|\
| H2O
|
Isopentenyl phosphate
|
| ATP
|/
| Isopentenyl phosphate kinase
|\
| ADP
|
Isopentenyl diphosphate


Bacterial version of Mevalonate phosphate to Isopentenyl diphosphate

Mevalonate phosphate
|
| ATP
|/
| Mevalonate phosphate kinase
|\
| ADP
|
Diphosphomevalonate
|
| Diphosphomevalonate decarboxylase (EC 4.1.1.33)
|\
| CO2
|
Isopentenyl diphosphate



Dimethylallyl diphosphate
|
| Isopentenyl-diphosphate delta-isomerase (EC 5.3.3.2)
| or
| Isopentenyl-diphosphate delta-isomerase, FMN-dependent (EC 5.3.3.2)
|
Isopentenyl diphosphate



Polyisoprenoids:

Glycerol-1-phosphate
|
| Geranylgeranyl pyrophosphate
|/
| (S)-3-O-geranylgeranylglyceryl phosphate synthase
|\
| PPi
|
(S)-3-O-geranylgeranylglyceryl phosphate
|
| Geranylgeranyl pyrophosphate
|/
| (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase
|\
| PPi
|
(S)-2,3-di-O-geranylgeranylglyceryl phosphate

----
(S)-3-O-geranylgeranylglyceryl phosphate synthase:

Identified in Methanothermobacter thermautotrophicus str. Delta H:
Soderberg, T., Chen, A., and Poulter, C. D. 2001. Geranylgeranylglyceryl phosphate synthase. Characterization of the recombinant enzyme from Methanobacterium thermoautotrophicum. Biochemistry 40: 14847-54.

Similar to


----
(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase:

Identified in.

Similar to PcrB gene of low-G+C gram positive bacteria (e.g., B. subtilis), a gene of unknown function.

Crystalized from Archaeoglobus fulgidus DSM 4304:
Payandeh, J., Fujihashi, M., Gillon, W., and Pai, E. F. 2006. The crystal structure of (S)-3-O-geranylgeranylglyceryl phosphate synthase reveals an ancient fold for an ancient enzyme. J. Biol. Chem. 281: 6070-8.

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LITERATURE